Process Model

Starting point of process development is the setup of the Process (see Framework overview) model, i.e., the specific configuration of the chromatographic process. This is realized using UnitOperations as building blocks. A UnitOperation represents the physico-chemical behavior of an apparatus and holds the model parameters. For more information refer to Unit Operation Models.

All UnitOperations can be associated with BindingModels that describe the interaction of components with surfaces or chromatographic stationary phases. For this purpose, a variety of equilibrium relations, for example,the simple Linear adsorption isotherm, competitive forms of the Langmuir and the BiLangmuir models, as well as the competitive StericMassAction law can be selected. For more information refer to Binding Models.

Moreover, ReactionModels can be used to model chemical reactions. For more information refer to Chemical Reactions.

Multiple UnitOperation can be connected in a FlowSheet which describes the mass transfer between the individual units. For more information refer to Flow Sheet.

Finally, dynamic Events can be defined to model dynamic changes of model parameters, including flow rates system connectivity. For more information refer to Process.

In the following, the different modules are introduced.

• Component System
• Binding Models
  • Multi-State Binding
• Chemical Reactions
  • Forward Reactions
  • Equilibrium Reactions
• Unit Operation Models
  • Polynomial Coefficients
  • Solution Recorder
• Flow Sheet
  • Adding Unit Operations
  • Adding Connections
  • Output State
  • Flow Rates
  • Marking Unit Operations for Performance Indicators
• Process
  • Event Dependencies
  • Specifying Indices of Multidimensional Parameters for Events
  • Generating Inlet Profiles from Existing Data
  • Parameter Sensitivities